منابع مشابه
Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression
Gastric carcinoma is the third leading cause of lethal cancer worldwide. Previous studies showed that Notch1 receptor intracellular domain (N1IC), the activated form of Notch1 receptor, promotes gastric cancer progression. It has been demonstrated that a significant cross-talk interplays between Notch pathways and microRNAs (miRNAs) in controlling tumorigenesis. This study identified an introni...
متن کاملPhosphorylation of Notch1 by Pim kinases promotes oncogenic signaling in breast and prostate cancer cells
Tumorigenesis is a multistep process involving co-operation between several deregulated oncoproteins. In this study, we unravel previously unrecognized interactions and crosstalk between Pim kinases and the Notch signaling pathway, with implications for both breast and prostate cancer. We identify Notch1 and Notch3, but not Notch2, as novel Pim substrates and demonstrate that for Notch1, the se...
متن کاملVisfatin promotes cell and tumor growth by upregulating Notch1 in breast cancer
Overexpression of Notch1 has been associated with breast cancer. We recently showed that visfatin stimulates breast cancer cell proliferation and invasion. The present study was undertaken to determine whether Notch1 signaling is affected by visfatin and to characterize the functional role of the visfatin-Notch1 axis in breast cancer. Visfatin and Notch1 were expressed at higher levels in breas...
متن کاملmicroRNA sponge upregulates Notch1 and promotes tumorigenesis of malignant
MicroRNA-146a Inhibits Glioma Development by Targeting Notch1 1 2 Running title: miR-146a restricts gliomagenesis 3 4 Jie Mei, Robert Bachoo, and Chun-Li Zhang 5 6 Department of Molecular Biology, Department of Neurology, University of Texas 7 Southwestern Medical Center, Dallas, TX 75390-9148 8 9 10
متن کاملNotch1 Activation or Loss Promotes HPV-Induced Oral Tumorigenesis.
Viral oncogene expression is insufficient for neoplastic transformation of human cells, so human papillomavirus (HPV)-associated cancers will also rely upon mutations in cellular oncogenes and tumor suppressors. However, it has been difficult so far to distinguish incidental mutations without phenotypic impact from causal mutations that drive the development of HPV-associated cancers. In this s...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.355.6331.1278-f